In the mini-series, Franco plays a divorced English teacher who discovers a time portal to 1958, giving him the opportunity to prevent the assassination of John F. Kennedy. Knight is set to play a Texan salesman whose wife falls in love with Franco, leading to a tense and dangerous confrontation between the men.
Hulu is yet to announce a release date for the series.
Knight, who has starred on Broadway in A life in the Theatre, Noises Off and Tartuffe among others, is also well known for his long-running role as Dr. George O'Malley in "Grey's Anatomy," for which he was Emmy-nominated, as well as for his performance in "The Good Wife."